Slide 1:
Hed: Treating Major Hyperoxaluria
Dek: This uncommon dysfunction causes kidney stones and presumably kidney harm. Discover out extra about your therapy choices.
Slide 2:
Major hyperoxaluria is a uncommon genetic dysfunction the place your physique creates an excessive amount of of a substance referred to as oxalate.
When an excessive amount of oxalate builds up within the kidneys and combines with calcium, it kinds kidney stones and might result in kidney failure.
Slide 3:
There are three forms of PH:
PH1
PH2
PH3
Remedy choices depend upon which sort of PH you could have, however the therapy purpose for all types of PH is to stop oxalate from increase within the kidneys and different components of your physique.
Slide 4:
Some therapy choices embody:
Vitamin B6 (pyridoxine)
When taken at excessive doses, vitamin B6 can assist decrease oxalate ranges. This therapy works for about 3 out of 10 individuals. It is just helpful for sufferers with PH1.
Slide 5:
Prescription Drugs
Lumasiran and nedosiran might be given as injections below the pores and skin to decrease oxalate ranges. These medicines are solely helpful for sufferers with PH1.
Slide 6:
Consuming Loads of Fluids
Consuming plenty of fluid (particularly water) every day can assist flush the oxalate out of your physique.
Slide 7:
Citrate or Bicarbonate Salts
An excessive amount of acid in your urine will increase the danger of kidney stones. Consuming citrate and bicarbonate salt like:
Potassium citrate
Potassium bicarbonate
Sodium citrate
Sodium bicarbonate
can decrease the acidity of your urine.
Slide 8:
Avoiding Excessive Ranges of Vitamin C
An excessive amount of vitamin C in your food regimen — from meals or dietary supplements — can increase oxalate.
Slide 9:
Avoiding Meals Excessive in Oxalate
Excessive-oxalate meals embody:
Nuts
Chocolate
Candy potatoes
Plums
Beets
Rhubarb
Spinach
Tofu
Strawberries
In case you select to eat these meals, eat calcium-rich meals as effectively to assist stop the oxalate from reaching your kidneys and creating kidney stones.
Slide 10:
How effectively main hyperoxaluria remedies work relies on your general well being and the way extreme your situation is.
Speak to your healthcare supplier about what may give you the results you want.
This academic useful resource was created with help from Alnylam.
